Peutz-Jeghers Syndrome: A Comprehensive Literature Review with Illustrative Case Series
1, 1, 1, 1, 1, 1, 1, 1, 1
- 1Department of Pharmacy Practice, Nirmala College of Pharmacy, Acharya Nagarjuna University, Atmakur, Mangalagiri, Guntur, Andhra Pradesh, INDIA.
CORRESPONDENCE
Ganjala Hemalatha
Department of Pharmacy Practice, Nirmala College of Pharmacy, Acharya Nagarjuna University, Atmakur, Mangalagiri, Guntur, Andhra Pradesh, INDIA.
Received: 03-03-2026; Accepted: 29-06-2026.
Volume 19, Issue 4 · pp. 557-560 · 2026 · DOI: 10.5530/ijopp.20260002
ABSTRACT
Peutz-Jeghers Syndrome (PJS) is a rare autosomal dominant disorder characterized by hamartomatous gastrointestinal polyps and mucocutaneous pigmentation, with an increased risk of malignancy. To present a comprehensive overview of PJS through literature review and illustrative case series highlighting clinical presentation, diagnosis, and management. Five illustrative cases are presented demonstrating varied clinical manifestations of PJS. Common presenting features included recurrent abdominal pain, anemia, and mucocutaneous pigmentation. Two cases presented with intussusception requiring surgical intervention, while others were managed with endoscopic polypectomy and surveillance. One case demonstrated malignant transformation, emphasizing cancer risk. Histopathological findings in all cases confirmed hamartomatous polyps. PJS exhibits diverse clinical presentations ranging from mild symptoms to severe complications. Early recognition and regular surveillance are essential to prevent morbidity and detect malignancy at an early stage.
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Hemalatha, G., Ramya, V., Pragna, G., Mitha, P. M., Muskan, S., Lavanya, K., Kavya, G. A., Rao, G. R. N., & Sandhya, V. (2026). Peutz-Jeghers Syndrome: A Comprehensive Literature Review with Illustrative Case Series. Indian Journal of Pharmacy Practice, 19(4), 557-560. https://doi.org/10.5530/ijopp.20260002
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0