Indian Journal of Pharmacy Practice logo
Submit
Indian Journal of Pharmacy PracticeACADEMIC PUBLISHING
Article

Assessment of Antibiotic Efficacy in the Management of “Priority 1: Critical” Multi-Drug Resistant Gram-Negative Bacterial Infections Enlisted by WHO

1, 1, 1

  1. 1Department of Pharmacy Practice, Rajiv Gandhi University of Health Sciences, Karnataka College of Pharmacy, Bangalore, Karnataka, INDIA..

CORRESPONDENCE

Morey Komal M

Department of Pharmacy Practice, Rajiv Gandhi University of Health Sciences, Karnataka College of Pharmacy, Bangalore, Karnataka, INDIA..

komalmmoreypharmd@gmail.com

Received: 09-08-2024; Accepted: 04-09-2024.

Volume 18, Issue 1 · pp. 71-83 · 2024 · DOI: 10.5530/ijopp.20250087

ABSTRACT

Background: The growing resistance pattern ofmultidrug-resistant gram-negative bacteria is increasing, making it more crucial to use antibiotics. Our study focuses on antibiotics’ rational use and efficacy for gram-negative bacterial infections. aim to find the susceptibility and the resistance pattern of the gram-negative bacteria-P. aeruginosa, K. pneumoniae, A. baumannii, andE. coli(Priority 1: Critical) to the antibiotics and to assess the antibiotic efficacy.Materials and Methods:It is a prospective observational study performed using an antibiogram to find susceptibility and the right use of the antibiotic for Priority 1: Critical species of gram-negative bacteria. The study involved 201 people and was carried out over a period of nine months. Statistical analysis was performed with the help of JASP software.Results:Escherichia colibeing the highest gram-negative causing bacterial infections have also made it very challenging to treat the infections due to its growing resistance pattern. our study showed that Cefoperazone+sulbactam and piperacillin+tazobactam are the most susceptible drugs. The highest-resistant drugs are carbapenem, meropenem, ampicillin and ertapenem. Student-paired T-test was performed for CRP, Procalcitonin and ESR; the results were statistically significant.Conclusion:This study interprets the growing and new pattern of MDR that has made it a very challenging aspect of the healthcare system. It emphasizes the appropriate usage of antibiotics for better infection control and good patient outcomes.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    M, M. K., Balakeshwa, R., & R, P. B. (2024). Assessment of Antibiotic Efficacy in the Management of “Priority 1: Critical” Multi-Drug Resistant Gram-Negative Bacterial Infections Enlisted by WHO. Indian Journal of Pharmacy Practice, 18(1), 71-83. https://doi.org/10.5530/ijopp.20250087

    Copyright and licence

    © 2024 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0