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Efficacy and safety of Rosuvastatin versus Atorvastatin in patients with Hypercholestrolemia

1, 2

  1. 1M. Pharm in Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana-384 001, Gujarat, INDIA.
  2. 2Head & Professor, Department of Pharmacology, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana-384 001, Gujarat, INDIA.

CORRESPONDENCE

Sanket S.S

M. Pharm in Clinical Pharmacy, Shri Sarvajanik Pharmacy College, Near Arvind Baug, Mehsana-384 001, Gujarat, INDIA.

sanket_s1110@yahoo.com

Received: 18-08-2012; Accepted: 12-03-2013.

Volume 6, Issue 1 · pp. 74-79 · 2013 · DOI:

ABSTRACT

The objective of the study was to measure efficacy and safety of Rosuvastatin-10mg versus Atorvastatin-20mg in patients with Hypercholesterolemia. We conducted a single centre retrospective study, involving 117 hypercholesterolemia patients between age group of 45-80 years. Data of both diabetic and nondiabetic patients with LDL-C: ≥140 - 60 mg/dl, Total Cholesterol: 200-240 mg/dl, Triglyceride: ≥165-≤400 mg/dl and VLDL: 40 mg and who were prescribed either Rosuvastatin 10mg or Atorvastatin 20mg were included in the study. Astatistically significant reduction in LDL-C, TG, TC and VLDL was seen in both the groups. Similarly a statistically significant increase in HDL-C levels was observed in both the groups. Rosuvastatin showed a statistically significant reduction in TG at week 12 as compared to Atorvastatin. Decrease in LDL-C, TC, TG and VLDL was 22.3%, 16.3%, 30.1% and 31% respectively in Rosuvastatin group while the reduction was 15.5%, 13.7%, 19.2% and 23.4% respectively in Atorvastatin group. Rosuvastatin showed a greater improvement in lipid parameters as compared to Atorvastatin though this difference was not statistically significant. Both treatments were well tolerated with similar incidence of adverse events (Rosuvastatin 10 mg: 6.25% as compared to Atorvastatin 20 mg: 7.55%).Rosuvastatin was more effective than Atorvastatin in reducing LDL-C, Total Cholesterol, Triglyceride and VLDL. It was also better in increasing HDL-C as compared to Atorvastatin. Rosuvastatin therefore seems to be a better alternative from other statins in patients having Hypercholesterolemia.

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    S.S, S., & I.S, A. (2013). Efficacy and safety of Rosuvastatin versus Atorvastatin in patients with Hypercholestrolemia. Indian Journal of Pharmacy Practice, 6(1), 74-79.

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    © 2013 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0