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Safety and efficacy of amiodarone in arrhythmias – a prospective study in the South Indian population

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  1. 1Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, INDIA.

CORRESPONDENCE

Vasantha Janardhan

Department of Pharmacy Practice, Faculty of Pharmacy, Sri Ramachandra University, Porur, Chennai-600 116, INDIA.

vasajan2001@hotmail.com

Received: 01-12-2009; Accepted: 05-01-2010.

Volume 2, Issue 3 · pp. 42-47 · 2009 · DOI:

ABSTRACT

To study the cardiac and non-cardiac safety of amiodarone and measure the efficacy of amiodarone in restoring and maintaining sinus rhythm. 35 patients on amiodarone therapy were examined for its safety and efficacy during a period of 6-months. The dosing schedule of amiodarone in the study population was as follows: I.V. loading doses of 150-300 mg bolus over 30 minutes, followed by 1 mg per minute for 6 hours, followed by daily oral maintenance dose of 100-400 mg; I.V. + oral loading dose of 800-2320 mg per day, to a total dose of up to 10 gm, followed by daily oral maintenance dose of 100-400 mg; Oral loading dose of 200 mg T.D.S. for 5 days followed by 200 mg B.D. for 5 days and a daily oral maintenance dose of 100-200 mg O.D. Out of 35 patients, only 2 patients developed severe ADR (hypothyroidism) and discontinued amiodarone therapy. Amiodarone could restore rhythm in 15 (83.33%) out of 18 patients with Ventricular Tachyarrhythmias (VT) and in 10 (83.33%) patients out of 12 patients with Atrial Fibrillation (AF). In other types of arrhythmias (Supraventricular Tachycardia (SVT), Ventricular Tachycardia (VT), Ventricular Premature Complexes (VPCs) & Supraventricular Premature Complexes (SVPCs), amiodarone could restore rhythm in 5 (100%) out of 5 patients. Amiodarone was found to be safe and effective in treating all types of arrhythmias.

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    Janardhan, V., K, K., S, R., N, V. R., G, K., G, J., & C, U. M. R. (2009). Safety and efficacy of amiodarone in arrhythmias – a prospective study in the South Indian population. Indian Journal of Pharmacy Practice, 2(3), 42-47.

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    © 2009 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0