Indian Journal of Pharmacy Practice logo
Submit
Indian Journal of Pharmacy PracticeACADEMIC PUBLISHING
Article

Isoniazid-Induced Lichenoid Drug Eruption: A Rare Case Report

1, 1, 1, 1, 1, 2

  1. 1Department of Pharmacy Practice, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA.
  2. 2Department of Dermatology, J N Medical College, Belagavi, Karnataka, INDIA.

CORRESPONDENCE

Mandati Santhosh Reddy

Department of Pharmacy Practice, KLE College of Pharmacy, Belagavi, KLE Academy of Higher Education and Research, Belagavi, Karnataka, INDIA.

santhoshreddy@klepharm.edu

Received: 16-12-2025; Accepted: 27-02-2026.

Volume 19, Issue 3 · pp. 426-430 · 2026 · DOI: 10.5530/ijopp.20260656

ABSTRACT

Lichenoid Drug Eruption (LDE) is a rare, immune-mediated adverse cutaneous reaction that closely mimics idiopathic lichen planus. Isoniazid, a first-line anti-tubercular drug, has been infrequently implicated as a causative agent. We report the case of a 55-year-old male with hypertension and pulmonary tuberculosis receiving multidrug anti-tubercular therapy, who developed multiple hyperpigmented macules, patches, and plaques over the trunk, limbs, and oral mucosa. Histopathological examination revealed features consistent with lichenoid dermatitis. The patient was managed with systemic corticosteroids, immunosuppressants, and supportive therapy while continuing anti-tubercular treatment. This case emphasizes the importance of recognizing isoniazid-induced cutaneous adverse reactions early, managing them effectively without discontinuing essential therapy, and ensuring multidisciplinary collaboration between dermatology, pulmonology, and pharmacy teams to achieve optimal outcomes.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Rajgoli, A., Tambe, A., Tewari, I., Reddy, M. S., Kini, P., & Doshi, B. (2026). Isoniazid-Induced Lichenoid Drug Eruption: A Rare Case Report. Indian Journal of Pharmacy Practice, 19(3), 426-430. https://doi.org/10.5530/ijopp.20260656

    Copyright and licence

    © 2026 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0