A Case Report on Nivolumab Induced Hypophysitis
1, 2, 3, 3
- 1Department of Clinical Pharmacy, Nazareth College of Pharmacy, Othera, Thiruvalla, Kerala, INDIA.
- 2Department of Pharmacy Practice, Srinivas College of Pharmacy, Mangalore, Karnataka, INDIA.
- 3Department of Endocrinology, Believers Church Medical College Hospital, Thiruvalla, Kerala, INDIA.
CORRESPONDENCE
Shone Padinjarethil George
Department of Endocrinology, Believers Church Medical College Hospital, Thiruvalla, Kerala, INDIA.
Received: 09-06-2025; Accepted: 13-10-2025.
Volume 19, Issue 2 · pp. 323-325 · 2025 · DOI: 10.5530/ijopp.20260599
ABSTRACT
Nivolumab, an immune checkpoint inhibitor, has revolutionized the treatment of various malignancies, including esophageal adenocarcinoma. However, its use is associated with immune-related Adverse Events (irAEs), including hypophysitis, a rare but potentially serious inflammation of the pituitary gland. This case report describes a patient with adenocarcinoma of the lower esophagus who developed hypophysitis after five cycles of nivolumab, presenting with hyponatremia and low cortisol levels. This case highlights the importance of recognizing and managing this endocrine irAE in patients undergoing immunotherapy.
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A, A., K, K., Finny, P., & George, S. P. (2025). A Case Report on Nivolumab Induced Hypophysitis. Indian Journal of Pharmacy Practice, 19(2), 323-325. https://doi.org/10.5530/ijopp.20260599
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This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0