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Exploring Semaglutide Effects on Osteoarthritis in Obesity: Emphasis on Weight Management and Inflammatory Responses

1, 1, 1, 1, 1

  1. 1Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Namakkal, Tamil Nadu, INDIA.

CORRESPONDENCE

Rabiyath Riswana Ismail

Department of Pharmacy Practice, Swamy Vivekanandha College of Pharmacy, Namakkal, Tamil Nadu, INDIA.

riswanarabiyadh@gmail.com

Received: 07-03-2025; Accepted: 29-08-2025.

Volume 19, Issue 1 · pp. 26-31 · 2025 · DOI: 10.5530/ijopp.20260437

ABSTRACT

Obesity frequently makes Osteoarthritis (OA), a degenerative joint disease, worse by increasing systemic inflammation and mechanical stress. Semaglutide is a medicine that helps people with type 2 diabetes and obesity. It works by making people lose weight. Recently, many researchers have been looking into how it might help in other ways. They want to know if it can be used for more than just weight loss and diabetes treatment. Semaglutide dual function in slowing the course of OA by encouraging substantial weight loss and modifying inflammatory pathways is examined in this review. Recent data indicates that semaglutide – induced weight loss reduces joint load, and its anti-inflammatory qualities may have a direct impact on the pathophysiology of OA. Gaining insight into these processes may help develop combined therapy plans that address OA and obesity.

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    Ravi, P., Ravi, P., Ismail, R. R., Jayaprakash, S., & Arumugam, P. (2025). Exploring Semaglutide Effects on Osteoarthritis in Obesity: Emphasis on Weight Management and Inflammatory Responses. Indian Journal of Pharmacy Practice, 19(1), 26-31. https://doi.org/10.5530/ijopp.20260437

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    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0