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Pharmacokinetics, Disease, and Equipment Related Factors Impacting Intensive Care Unit Patient Outcomes: Comprehensive Review

1, 1, 1, 1, 1, 2, 2

  1. 1Department of Pharmacy Practice, Nirmala College of Pharmacy, Mangalagiri, Atmakur, Andhra Pradesh, INDIA..
  2. 2Department of Pharmacology and Pharmacy Practice, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, INDIA..

CORRESPONDENCE

Komaragiri Krishna

Department of Pharmacology and Pharmacy Practice, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, INDIA..

kkrishna9117@gmail.com

Received: 03-11-2024; Accepted: 22-12-2024.

Volume 18, Issue 3 · pp. 249-256 · 2025 · DOI: 10.5530/ijopp.20250209

ABSTRACT

In unconscious patients, managing treatment presents significant challenges due to the inability to gauge subjective effects and the complexities of altered pharmacokinetics. Critical illness often modifies drug absorption, distribution, metabolism, and excretion, necessitating frequent adjustments in dosing. Additionally, polypharmacy increases the risk of drug interactions, complicating therapy. The absence of patient feedback and the unpredictable nature of drug responses demand meticulous monitoring and individualized treatment plans. Effective management relies on close collaboration among healthcare providers, ongoing therapeutic drug monitoring, and tailored dosing strategies to optimize safety and efficacy. Addressing these issues is crucial for ensuring appropriate and effective drug therapy in this vulnerable population.

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    Praneetha, A., Sathwika, M. H., Rahimunnisa, S., Lokeswari, P., Dikshitha, A., Ramya, S., & Krishna, K. (2025). Pharmacokinetics, Disease, and Equipment Related Factors Impacting Intensive Care Unit Patient Outcomes: Comprehensive Review. Indian Journal of Pharmacy Practice, 18(3), 249-256. https://doi.org/10.5530/ijopp.20250209

    Copyright and licence

    © 2025 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0