Indian Journal of Pharmacy Practice logo
Submit
Indian Journal of Pharmacy PracticeACADEMIC PUBLISHING
Article

Prednisolone Induced Systemic Toxicity in Case of Steroid Sensitive Nephrotic Syndrome

1, 1, 1

  1. 1Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA.

CORRESPONDENCE

Nishi Sheth

Department of Pharmacy, Sumandeep Vidyapeeth (Deemed to be University), Piparia, Waghodia, Vadodara, Gujarat, INDIA.

nishisheth72@gmail.com

Volume 14, Issue 3 · pp. 230-232 · 2021 · DOI: 10.5530/ijopp.14.3.47

ABSTRACT

Prednisolone is a corticosteroid, it works on immune system to relieve swelling, redness, and inflammation.it is a choice of drug for arthritis, cancer, asthma, allergic condition, bell’s palsy, Nephrotic syndrome and disorders of endocrine system. Prednisolone helps decreasing inflammation by suppression of leukocytes and decrease expression of pro-inflammatory markers. Nephrotic syndrome is a condition in which damage kidney glomeruli which leaks protein into urine from blood. In pediatric population the choice of drug selected is prednisolone which resolves the symptoms and reduces infection. Prednisolone is the drug considered for the frequently relapsing Nephrotic syndrome. It should be given on alternate basis. for patient with infrequent relapses, therapy should be not prolonged. Adverse effects of prednisolone are hypertension, adrenal suppression, osteoporosis, diabetes mellitus, poor growth and cushingoid syndrome. Systemic toxicity due to prednisolone in pediatric patient increases the risk of infection and pre-renal failure. In this case report, it is summarized that despite of everyday prednisolone intake, alternate day therapy is more effective and causes less side effects. Proper monitoring is necessary and timely laboratory findings should be obtained for less adverse events.

KEYWORDS

Open in new tab

REFERENCES

As published

Showing references and in-text citations exactly as published.

    Cite this article

    SELECT FORMAT

    Sheth, N., Zaveri, D., & Rajput, H. S. (2021). Prednisolone Induced Systemic Toxicity in Case of Steroid Sensitive Nephrotic Syndrome. Indian Journal of Pharmacy Practice, 14(3), 230-232. https://doi.org/10.5530/ijopp.14.3.47

    Copyright and licence

    © 2021 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0