A Case Report on Methotrexate Overdose Induced Pancytopenia and Mucocutaneous Ulcerations
1, 1, 2, 3, 3, 3, 3
- 1Department of Internal Medicine, Aster CMI Hospital, Bangalore, Karnataka, INDIA.
- 2Clinical Pharmacologist, Aster CMI Hospital, Bangalore, Karnataka, INDIA.
- 3Department of Pharmacy Practice, Bangalore, Karnataka, INDIA.
CORRESPONDENCE
Aneena Annu Philip
Department of Pharmacy Practice, Bangalore, Karnataka, INDIA.
Volume 13, Issue 4 · pp. 359-361 · 2020 · DOI: 10.5530/ijopp.13.4.61
ABSTRACT
Methotrexate (MTX) is commonly used in autoimmune conditions including rheumatoid arthritis, psoriasis, lupus, sarcoidosis and eczema due to its anti-inflammatory and immunosuppressive effect. The following report describes the case of a 55 year old female presenting with complaints of erythematous rashes over the limbs, oral and vaginal haemorrhagic mucositis. She was previously diagnosed with psoriasis and was on MTX 15mg weekly but the patient had taken it continuously resulting in toxicity. She was hospitalised, MTX withdrawn and treated with folinic acid. Our case highlights the importance of counselling in order to ensure adherence to the correct MTX treatment regimen to prevent toxicity and its serious effects.
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Srinivasa, B. M., Padmini, S., Kumar, P., Philip, A. A., Presannan, A. K., Thomas, R., & Arif, A. (2020). A Case Report on Methotrexate Overdose Induced Pancytopenia and Mucocutaneous Ulcerations. Indian Journal of Pharmacy Practice, 13(4), 359-361. https://doi.org/10.5530/ijopp.13.4.61
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© 2020 Author(s)
This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0