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Drug Induced Hypersensitivity Syndrome Secondary to Phenobarbitone

1, 1, 1, 2, 1, 1, 3, 3, 4

  1. 1Department of Pharmacy Practice, BLDEA's SSM College of Pharmacy and Research Centre, Vijayapura, Karnataka, INDIA.
  2. 2Department of Dermatology, Shri BM Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka, INDIA.
  3. 3Department of Pharmacology, Shri BM Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka, INDIA.
  4. 4Department of Surgery, Shri BM Patil Medical College Hospital and Research Centre, Vijayapura, Karnataka, INDIA.

CORRESPONDENCE

Syed Zia Inamdar

Department of Pharmacy Practice, BLDEA's SSM College of Pharmacy and Research Centre, Vijayapura, Karnataka, INDIA.

syedzia.inamdar@gmail.com

Volume 13, Issue 3 · pp. 283-286 · 2020 · DOI: 10.5530/ijopp.13.3.48

ABSTRACT

Phenobarbitone- a barbiturate, non-selective central nervous system depressant drug, primarily used as a sedative hypnotic and anticonvulsant in sub hypnotic doses. It has long term anticonvulsant effect, used in the treatment of generalized tonic-clonic and cortical local seizures. It is also effective in acute convulsive episodes associated with status epileptic’s cholera, eclampsia, meningitis, tetanus and toxic reactions to strychnine or local anesthetics. The present case report describes the occurrence of anticonvulsant drug induced hypersensitivity drug reaction followed after to the use of phenobarbitone in a pediatric patient prescribed to treat his seizure disorder. The suspected drug was immediately stopped and the patient was managed symptomatically. The causality assessment of the adverse effect revealed a “probable” causal relationship for the suspected drug and reaction was categorized as “moderately severe” in nature.

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    Inamdar, S. Z., Jakanur, S., Katragadda, P., Janagond, A., Paramagond, M., Kulkarni, R. V., Naikwadi, A., Koth, A., & Patil, A. (2020). Drug Induced Hypersensitivity Syndrome Secondary to Phenobarbitone. Indian Journal of Pharmacy Practice, 13(3), 283-286. https://doi.org/10.5530/ijopp.13.3.48

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    © 2020 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0