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Sulfamethoxazole+Trimethoprim Induced Stevens- Johnson Syndrome in HIV Patient: A Case Report

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  1. 1Department of Pharmacy Practice, Basaweshwar Teaching and General Hospital, HKES’s College of Pharmacy (MTRIPS), Sedam Road, Gulbarga, Karnataka, INDIA.

CORRESPONDENCE

Manjunath Gandage

Department of Pharmacy Practice, Basaweshwar Teaching and General Hospital, HKES’s College of Pharmacy (MTRIPS), Sedam Road, Gulbarga, Karnataka, INDIA.

mggandage@gmail.com

Volume 12, Issue 4 · pp. 283-285 · 2019 · DOI: 10.5530/ijopp.12.4.60

ABSTRACT

Stevens-Johnson syndrome is mucocutaneous cellmediated hypersensitivity reaction which affects 2 to 3 cases per million. SJS is generally rare, but potentially lifethreatening and commonly drug induced. Trimethoprimsulfamethoxazole (TMP/SMX) is a widely prescribed antimicrobial for the management of several uncomplicated infections. It is commonly used for the treatment and prophylaxis of Pneumocystis Jirovecii Pneumonia (PCP) in the HIV-infected population. The adverse reaction to TMP/SMX is more frequent and severe in HIV-infected patients as compared to the general population. We report a case of 39-year-old male patient admitted into male medical free ward with a chief complaints of fever, difficulty in swallowing, skin lesions over the body from 4 days. Multiple well-defined erythematous macules, Erosion and crustations on angle of the mouth, Genital Involvement, Acute Conjuctivitis are observed. These clinical manifestations are observed after taking sulfamethoxazole+trimethoprim on 5th day. Based on the above clinical investigations it is diagnosed as sulfamethoxazole+trimethoprim induced Stevens-Johnson syndrome.

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    Gandage, M., Panumetcha, G., Patil, N., Salimath, P., Kumar, H., & Ninne, S. (2019). Sulfamethoxazole+Trimethoprim Induced Stevens- Johnson Syndrome in HIV Patient: A Case Report. Indian Journal of Pharmacy Practice, 12(4), 283-285. https://doi.org/10.5530/ijopp.12.4.60

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    © 2019 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0