Study of Prescribing Pattern of Antihypertensive Drugs and Evaluation of the Prescription with JNC 8 Guidelines in North Karnataka Hospital

ABSTRACT

Aim: To conduct a prospective observational study on prescribing pattern of antihypertensive drugs and to evaluate the current practice of antihypertensive drug by comparing with JNC-8 guidelines in north Karnataka hospital.Methods: The study was conducted for a period of 6 months with a sample size of 100 of all the in-patient of age ≥ 18 years of hypertension with or without co-morbidities, including pregnant women and lactating mothers.Results: A total of 100 prescriptions were analysed during the six-month study period. 55% were male while 45% were female. 25% patients received monotherapy while majority of the patient’s i.e. 75% were put on multidrug therapy of which, 35% patients on two drug therapy, 32% of patients on three drug therapy and 8% on four drug therapy. The most common drug classes involved in the study were ARBs (17%), BBs (09%) and ACEIs (03%). Our study reveals that without diabetes or CKD (greater than 60 years) 75.60% of patients were compliant with JNC-8 goal (less than 150/90 mmHg) and without diabetes or CKD (less than 60 years) 64.30% of patients were compliant with JNC-8 goal (less than140/90 mmHg). Patients with diabetes and without CKD (all ages) 50% achieved the JNC-8 goal (less than140/90 mmHg) and Patients with CKD or without DM (all ages and races) 60% achieved the JNC-8 goal (less than140/90 mmHg).Conclusion: Calcium channel blockers (Amlodipine) and diuretics (Furosemide) were the drug of choice for hypertensive patients as a single drug and combination drug therapy. As per the JNC 8 guidelines majority of the BP goals were achieved. Our result reveals that antihypertensive medication adherence to JNC 8 guidelines is optimal at the study site.

KEYWORDS

• Prescription pattern
• Anti-hypertensive
• In-patients
• JNC-8
• Co-Morbidities

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• DOI10.5530/ijopp.11.4.40Copy

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© 2018 Author(s)

This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0

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