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Isoniazid Associated Psychosis: A Case Series of 3 Patients

1, 2, 3, 4, 5

  1. 1Doctoral Research Scholar, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.
  2. 2Pharm.D Intern, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.
  3. 3Associate Professor, Department of General Medicine, JSS Medical College & Hospital, JSS University, Mysore- 15, Karnataka, INDIA.
  4. 4Associate Professor, Department of General Medicine, JSS Medical College & Hospital, JSS University, Mysore- 15, Karnataka, INDIA.
  5. 5Professor and Head, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.

CORRESPONDENCE

Vineetha Bharathan Menon

Doctoral Research Scholar, Department of Pharmacy Practice, JSS College of Pharmacy, JSS University, Mysore- 15, Karnataka, INDIA.

vineethamenon54@yahoo.com

Volume 10, Issue 2 · pp. 142-146 · 2017 · DOI: 10.5530/ijopp.10.2.29

ABSTRACT

Background: Isoniazid is the first line agent for the treatment of tuberculosis. Psychosis is a known complication of isoniazid therapy, although infrequent. Case report: One female and two male patients aged 35 years, 55 years and 60 years respectively developed psychosis following isoniazid administration. All the three received 300 mg of isoniazid daily for the management of pulmonary tuberculosis. High dose of isoniazid and low body mass index were identified as the common risk factor for the development of isoniazid associated psychosis. The incidence, possible pathogenesis, risk factors and treatment options are discussed.Conclusion: Isoniazid psychosis is a major complication, which if recognized early can be effectively treated.

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    Menon, V. B., Shaji, R., Pereira, P., Chikkaveeraiah, S. K., & Ramesh, M. (2017). Isoniazid Associated Psychosis: A Case Series of 3 Patients. Indian Journal of Pharmacy Practice, 10(2), 142-146. https://doi.org/10.5530/ijopp.10.2.29

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    © 2017 Author(s)

    This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. CC BY 4.0